Endocrine Abstracts

Objective: The goal of this study is to evaluate the relationship between levels of adiponectin and vaspin, adiponectin/vaspin (A/V) ratio and metabolic syndrome, degree of adiposity, and insulin resistance (IR), as well as their correlation with metabolic variables.Methods: Two hundred sixty patients with newly diagnosed type 2 diabetes (126 male, 134 female) were enrolled. Patients were grouped based on degree of adiposity, IR assessment (homeostasis m...

A 74-year-old diabetic lady presented to emergency-department following a collapse due to hypoglycaemia (blood glucose 1.7 mmol/l) and responded dramatically to intravenous–glucose. She had recurrent hypoglycaemic episodes in the last-fortnight, despite discontinuation of her oral hypoglycaemics and no other obvious precipitating factors/toxins like alcohol. She was on prednisolone, 10 mg along with azathioprine, 150 mg, atenolol, 25 mg, and candesartan, 8 mg. She has rhe...

Background: TMEM127 encodes for a ubiquitously expressed transmembrane protein with limited knowledge into its role. TMEM127 germline loss-of-function is a driver of pheochromocytoma and paraganglioma (PPGLs), tumors derived from the adrenal medulla and extra-adrenal paraganglia, respectively. Molecularly, TMEM127 mutant PPGLs belong to the kinase cluster, characterized by kinase signaling transcriptional programs. Receptor tyrosine kinase RET, a driver of PPGLs via germline o...